A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth.

ABSTRACT: The exact mechanism controlling cell growth remains a grand challenge in developmental biology and regenerative medicine. The Drosophila wing disc tissue serves as an ideal biological model to study mechanisms involved in growth regulation. Most existing computational models for studying tissue growth focus specifically on either chemical signals or mechanical forces. Here we developed a multiscale chemical-mechanical model to investigate the growth regulation mechanism based on the dynamics of a morphogen gradient. By comparing the spatial distribution of dividing cells and the overall tissue shape obtained in model simulations with experimental data of the wing disc, it is shown that the size of the domain of the Dpp morphogen is critical in determining tissue size and shape. A larger ti

SUBMITTER: Ramezani A 

PROVIDER: S-EPMC10199952 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature