Circadian Disruption and Colorectal Cancer Incidence in Black Women.

ABSTRACT:

Background

Animal and experimental studies suggest circadian disruption increases colorectal cancer risk, but evidence in humans is limited. We examined night shift work, chronotype, and residential position within a time zone, proxies for circadian disruption, in relation to colorectal cancer risk.

Methods

Participants in the Black Women's Health Study, a prospective cohort of 59,000 Black American women established in 1995, reported history of night shift work and chronotype on follow-up questionnaires. Residential position within a time zone was estimated using participant addresses at each questionnaire cycle. Number of colorectal cancer cases and follow-up duration varied by analysis depending on timing of exposure assessment, ranging from 204 over the 2005 to 2018 nigh

SUBMITTER: Barber LE 

PROVIDER: S-EPMC10199956 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature