Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice.

ABSTRACT:

Background

Altered social behavior is one of the symptoms of Alzheimer's disease (AD) that results in social withdrawal and loneliness and provides a major burden on patients and their relatives. Furthermore, loneliness is associated with an increased risk to develop AD and related dementias.

Objective

We aimed to investigate if altered social behavior is an early indicator of amyloid-β (Aβ) pathology in J20 mice, and if co-housing with wild type (WT) mice can positively influence this social phenotype.

Methods

The social phenotype of group-housed mice was assessed using an automated behavioral scoring system for longitudinal recordings. Female mice were housed in a same-genotype (4 J20 or WT mice per colony) or mixed-genotype (2 J20 mice + 2 WT mice) colony. At 10 we

SUBMITTER: Lanooij SD 

PROVIDER: S-EPMC10200156 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature