An Exploratory Study Using Electronic Medical Records to Assess the Feasibility of Establishing Cohorts of Patients with Genetic Causes of Parkinson's Disease.

ABSTRACT:

Background

More efficient screening methods are needed to improve the ability to identify and follow genetic cohorts in Parkinson's disease (PD).

Objective

To explore the use of the electronic medical records (EMRs) to identify participants with PD.

Methods

Using an algorithm previously developed in collaboration with Maccabi Healthcare Services (MHS), approximately 5,200 participants with PD were identified, more than 3,200 were screened, and 837 participants were enrolled and genotyped for leucine-rich repeat kinase 2 (LRRK2) and beta-glucocerebrosidase (GBA) variants. Questionnaires were completed to ascertain Ashkenazi Jewish (AJ) ancestry and family history of PD.

Results

Among 837 participants with PD, 82% were 65 years and older and 72% had a family hist

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC10200166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature