Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline.

ABSTRACT:

Background

Preclinical Alzheimer's disease (AD) is one possible cause of subjective cognitive decline (SCD). Normal task performance despite ongoing neurodegeneration is typically considered as neuronal compensation, which is reflected by greater neuronal activity. Compensatory brain activity has been observed in frontal as well as parietal regions in SCD, but data are scarce, especially outside the memory domain.

Objective

To investigate potential compensatory activity in SCD. Such compensatory activity is particularly expected in participants where blood-based biomarkers indicated amyloid positivity as this implies preclinical AD.

Methods

52 participants with SCD (mean age: 71.00±5.70) underwent structural and functional neuroimaging (fMRI), targeting episodic memor

SUBMITTER: Krebs C 

PROVIDER: S-EPMC10200167 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature