The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women.

ABSTRACT:

Background

Cognitive and brain reserve refer to individual differences that allow some people to better withstand brain pathology than others. Although early life stress has been recognized as a risk factor for low reserve in late life, no research yet has studied this across midlife.

Objective

To examine the associations of life stress with brain and cognitive reserve in midlife.

Methods

We included 1,232 middle-aged women who participated in the ORACLE Study between 2002-2006). Life stress was calculated as the shared variance of four cumulative stress domains, created from items measured between pregnancy and 10 years after childbirth. Brain reserve was defined as healthy-appearing brain volume measured with MRI; cognitive reserve as better cognitive functioning th

SUBMITTER: Schuurmans IK 

PROVIDER: S-EPMC10200172 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature