Therapeutic Potential of Microbiota Modulation in Alzheimer's Disease: A Review of Preclinical Studies.

ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disease, yet it currently lacks effective treatment due to its complex etiology. The pathological changes in AD have been linked to the neurotoxic immune responses following aggregation of Aβ and phosphorylated tau. The gut microbiota (GM) is increasingly studied for modulating neuroinflammation in neurodegenerative diseases and in vivo studies emerge for AD. This critical review selected 7 empirical preclinical studies from 2019 onwards assessing therapy approaches targeting GM modulating microglia neuroinflammation in AD mouse models. Results from probiotics, fecal microbiota transplantation, and drugs were compared and contrasted, including for cognition, neuroinflammation, and toxic aggregation of proteins. Studies co

SUBMITTER: Benichou Haziot C 

PROVIDER: S-EPMC10200201 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature