Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort.

ABSTRACT:

Background

The aging Mexican American (MA) population is the fastest growing ethnic minority group in the US. MAs have a unique metabolic-related risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI), compared to non-Hispanic whites (NHW). This risk for cognitive impairment (CI) is multifactorial involving genetics, environmental, and lifestyle factors. Changes in environment and lifestyle can alter patterns and even possibly reverse derangement of DNA methylation (a form of epigenetic regulation).

Objective

We sought to identify ethnicity-specific DNA methylation profiles that may be associated with CI in MAs and NHWs.

Methods

DNA obtained from peripheral blood of 551 participants from the Texas Alzheimer's Research and Care Consortium was typed on th

SUBMITTER: Abraham Daniel A 

PROVIDER: S-EPMC10200223 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature