A Preliminary Comparison of the Methylome and Transcriptome from the Prefrontal Cortex Across Alzheimer's Disease and Lewy Body Dementia.

ABSTRACT:

Background

Pathological amyloid-β and α-synuclein are associated with a spectrum of related dementias, ranging from Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) to Parkinson disease dementia (PDD). While these diseases share clinical and pathological features, they also have unique patterns of pathology. However, epigenetic factors that contribute to these pathological differences remain unknown.

Objective

In this preliminary study, we explore differences in DNA methylation and transcription in five neuropathologically defined groups: cognitively unimpaired controls, AD, pure DLB, DLB with concomitant AD (DLBAD), and PDD.

Methods

We employed an Illumina Infinium 850k array and RNA-seq to quantify these differences in DNA methylation and transcri

SUBMITTER: Fisher DW 

PROVIDER: S-EPMC10200238 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature