Stimulating native seizures with neural resonance: a new approach to localize the seizure onset zone.

ABSTRACT: Successful outcomes in epilepsy surgery rely on the accurate localization of the seizure onset zone. Localizing the seizure onset zone is often a costly and time-consuming process wherein a patient undergoes intracranial EEG monitoring, and a team of clinicians wait for seizures to occur. Clinicians then analyse the intracranial EEG before each seizure onset to identify the seizure onset zone and localization accuracy increases when more seizures are captured. In this study, we develop a new approach to guide clinicians to actively elicit seizures with electrical stimulation. We propose that a brain region belongs to the seizure onset zone if a periodic stimulation at a particular frequency produces large amplitude oscillations in the intracranial EEG network that propagate seizure activit

SUBMITTER: Smith RJ 

PROVIDER: S-EPMC10200285 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature