The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping.

ABSTRACT: Wernicke's area has been assumed since the 1800s to be the primary region supporting word and sentence comprehension. However, in 2015 and 2019, Mesulam and colleagues raised what they termed the 'Wernicke conundrum', noting widespread variability in the anatomical definition of this area and presenting data from primary progressive aphasia that challenged this classical assumption. To resolve the conundrum, they posited a 'double disconnection' hypothesis: that word and sentence comprehension deficits in stroke-based aphasia result from disconnection of anterior temporal and inferior frontal regions from other parts of the brain due to white matter damage, rather than dysfunction of Wernicke's area itself. To test this hypothesis, we performed lesion-deficit correlations, including connec

SUBMITTER: Matchin W 

PROVIDER: S-EPMC10200287 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature