Source-sink connectivity: a novel interictal EEG marker for seizure localization.

ABSTRACT: Over 15 million epilepsy patients worldwide have drug-resistant epilepsy. Successful surgery is a standard of care treatment but can only be achieved through complete resection or disconnection of the epileptogenic zone, the brain region(s) where seizures originate. Surgical success rates vary between 20% and 80%, because no clinically validated biological markers of the epileptogenic zone exist. Localizing the epileptogenic zone is a costly and time-consuming process, which often requires days to weeks of intracranial EEG (iEEG) monitoring. Clinicians visually inspect iEEG data to identify abnormal activity on individual channels occurring immediately before seizures or spikes that occur interictally (i.e. between seizures). In the end, the clinical standard mainly relies on a small propo

SUBMITTER: Gunnarsdottir KM 

PROVIDER: S-EPMC10200292 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature