Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.

ABSTRACT:

Background

Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.

Methods

We randomly assigned patients undergoing cesarean delivery at 31 U.S. hospitals to receive either tranexamic acid or placebo after umbilical-cord clamping. The primary outcome was a composite of maternal death or blood transfusion by hospital discharge or 7 days post partum, whichever came first. Key secondary outcomes were estimated intraoperative blood loss of more than 1 liter (prespecified as a major secondary outcome), interventions for bleeding and related complications, the preoperative-to-postoperative change in the hemoglobin level, and postpartum infectious complic

SUBMITTER: Pacheco LD 

PROVIDER: S-EPMC10200294 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature