The determinants of maternal homocysteine in pregnancy: findings from the Ottawa and Kingston Birth Cohort.

ABSTRACT:

Objective

Observational studies have linked elevated homocysteine to vascular conditions. Folate intake has been associated with lower homocysteine concentration, although randomised controlled trials of folic acid supplementation to decrease the incidence of vascular conditions have been inconclusive. We investigated determinants of maternal homocysteine during pregnancy, particularly in a folic acid-fortified population.

Design

Data were from the Ottawa and Kingston Birth Cohort of 8085 participants. We used multivariable regression analyses to identify factors associated with maternal homocysteine, adjusted for gestational age at bloodwork. Continuous factors were modelled using restricted cubic splines. A subgroup analysis examined the modifying effect of MTHFR 677C>T ge

SUBMITTER: Chaudhry SH 

PROVIDER: S-EPMC10200619 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature