Blinding integrity of dorsomedial prefrontal intermittent theta burst stimulation in depression.

ABSTRACT:

Background

The antidepressant effect of repetitive transcranial magnetic stimulation (rTMS) is partly placebo, making blinding integrity important. Blinding of high-frequency rTMS and intermittent theta burst stimulation (iTBS) has been reported as successful at study end. However, blinding integrity at study start is rarely reported. The aim of this study was to investigate blinding integrity during a treatment course of iTBS over the dorsomedial prefrontal cortex (DMPFC) in depression.

Methods

Forty-nine patients with depression from a double-blind-designed randomized controlled trial (NCT02905604) were included. Patients received either active or sham iTBS over the DMPFC with a placebo coil. The sham group received iTBS-synchronized transcutaneous electrical nerve stimula

SUBMITTER: Bengtsson J 

PROVIDER: S-EPMC10200834 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature