Gut microbial profile of treatment-naive patients with primary biliary cholangitis.

ABSTRACT:

Background and aims

The pathogenesis of primary biliary cholangitis (PBC) is associated with alterations of gut microbiota. We compared the gut microbiota of PBC patients and healthy controls from Zhejiang Province and assessed the use of these data for the diagnosis of PBC.

Methods

First, 16S rRNA gene sequencing was used to characterize the gut microbiota of treatment-naive PBC patients (n=25) and matched healthy controls (n=25). Then, the value of gut microbiota composition for the diagnosis of PBC and assessment of PBC severity was determined.

Results

The gut microbiota of PBC patients had lower diversity based on three different metrics of alpha-diversity (ace, Chao1, and observed features) and fewer overall genera (all p<0.01). PBC patients had significant enric

SUBMITTER: Zhou YJ 

PROVIDER: S-EPMC10200865 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature