Proteomic analysis of urinary extracellular vesicles highlights specific signatures for patients with primary aldosteronism.

ABSTRACT:

Background

Urinary extracellular vesicles (uEVs) can be released by different cell types facing the urogenital tract and are involved in cellular trafficking, differentiation and survival. UEVs can be easily detected in urine and provide pathophysiological information "in vivo" without the need of a biopsy. Based on these premises, we hypothesized that uEVs proteomic profile may serve as a valuable tool in the differential characterization between Essential Hypertension (EH) and primary aldosteronism (PA).

Methods

Patients with essential hypertension (EH) and PA were enrolled in the study (EH= 12, PA=24: 11 Bilateral Primary Aldosteronism subtype (BPA) and 13 Aldosterone Producing Adenoma (APA)). Clinical and biochemical parameters were available for all the subjects.

SUBMITTER: Bertolone L 

PROVIDER: S-EPMC10200877 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature