An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa.

ABSTRACT:

Background and aim

Type I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory molecules are not well understood. Adenosine deaminase acting on RNA 1 (ADAR1), an RNA-editing enzyme, plays a crucial role in inhibiting self or viral RNAs from activating auto-immune mediated responses, most notably within the type-I IFN production pathway. The aim of this study was to assess whether ADAR1 could contribute to the induction and/or progression of gut inflammation in patients with celiac disease.

Material and methods

ADAR1 expression was assessed by Real time PCR and Western blotting in duodenal biopsy taken from in

SUBMITTER: Di Fusco D 

PROVIDER: S-EPMC10200931 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature