Mendelian randomization indicates a causal contribution of type 2 diabetes to retinal vein occlusion.

ABSTRACT:

Background

Retinal vein occlusion (RVO) is a common retinal vascular disease that can cause severe visual impairment. Many observational studies have shown that type 2 diabetes (T2DM) is associated with RVO, but it remains unknown if the association is causal. The present study aimed to perform Mendelian randomization (MR) analyses to evaluate the causal contribution of genetically predicted T2DM to RVO.

Methods

We obtained summary-level data from a genome-wide association study meta-analysis including 48,286 cases and 250,671 controls for T2DM and from a genome wide association study of 372 cases and 182,573 controls in the FinnGen project for RVO. To verify the robustness of the results, an independent validation dataset for T2DM (12,931 cases and 57,196 controls) was used

SUBMITTER: Huang J 

PROVIDER: S-EPMC10200935 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature