Evaluation of efficacy and safety of glucokinase activators-a systematic review and meta-analysis.

ABSTRACT:

Aims

Glucokinase activators (GKAs) promote the activity of glucokinase (GK) and is under development for the treatment of diabetes. The efficacy and safety of GKAs require evaluation.

Methods

This meta-analysis included randomized controlled trials (RCTs) with a duration of at least 12 weeks conducted in patients with diabetes. The primary objective of this meta-analysis was the difference of hemoglobin A1c (HbA1c) change from baseline to study end between GKA groups and placebo groups. Risk of hypoglycemia and laboratory indicators were also evaluated. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for the continuous outcomes, and odds ratios (ORs) and 95% CI were calculated for the risk of hypoglycemia.

Results

Data from 13 RCTs

SUBMITTER: Yang W 

PROVIDER: S-EPMC10200948 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature