Increased meso-striatal connectivity mediates trait impulsivity in FTO variant carriers.

ABSTRACT:

Objective

While variations in the first intron of the fat mass and obesity-associated gene (FTO, rs9939609 T/A variant) have long been identified as a major contributor to polygenic obesity, the mechanisms underlying weight gain in risk allele carriers still remain elusive. On a behavioral level, FTO variants have been robustly linked to trait impulsivity. The regulation of dopaminergic signaling in the meso-striatal neurocircuitry by these FTO variants might represent one mechanism for this behavioral alteration. Notably, recent evidence indicates that variants of FTO also modulate several genes involved in cell proliferation and neuronal development. Hence, FTO polymorphisms might establish a predisposition to heightened trait impulsivity during

SUBMITTER: Edwin Thanarajah S 

PROVIDER: S-EPMC10200952 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature