Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a Mendelian randomization analysis.

ABSTRACT:

Background

Allergic conjunctivitis is an ocular immune disease which affects the conjunctiva, eyelids, and cornea. Growing evidence implicates the gut microbiota in balancing and modulating immunity response, and in the pathogenesis of allergic disease. As a result, gut microbial imbalance could be a useful indicator for allergic conjunctivitis. From the perspective of predictive, preventive, and personalized medicine (PPPM), clarifying the role of gut microbial imbalance in the development of allergic conjunctivitis could provide a window of opportunity for primary prediction, targeted prevention, and personalized treatment of the disease.

Working hypothesis and methodology

In our study, we hypothesized that individuals with microbial dysbiosis may be more susceptible to al

SUBMITTER: Liu K 

PROVIDER: S-EPMC10201039 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature