Performance characteristics of diagnostic assays for schistosomiasis in Ontario, Canada.

ABSTRACT:

Introduction

Due to lower intensity of infection and greater intervals from last exposure, parasitologic detection methods for schistosomiasis are poorly sensitive in non-endemic areas, challenging accurate diagnosis.

Methods

We evaluated parasitologic versus indirect detection methods for schistosomiasis. We included specimens submitted for Schistosoma serology, and stool for ova and parasite microscopy. Three real-time PCR assays targeting Schistosoma mansoni and S. haematobium were performed. Primary outcome measures were sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), where both microscopy and serology were the composite reference standard against serum PCR.

Results

Of 8168 serum specimens

SUBMITTER: Lau R 

PROVIDER: S-EPMC10201143 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature