Evaluation of singlet oxygen generators of novel water-soluble perylene diimide photosensitizers.

ABSTRACT: In this study, novel photosensitizers using three water-soluble green perylene diimide (PDI)-based ligands were synthesized, which can be used as photosensitizing drugs in photodynamic cancer therapy (PDT). These three efficient singlet oxygen generators were prepared via reactions of three newly designed molecules, namely 1,7-di-3-morpholine propylamine-N,N'-(l-valine-t-butylester)-3,4:9,10-perylyne diimide, 1,7-dimorpholine-N,N'-(O-t-butyl-l-serine-t-butylester)-3,4:9,10-perylene diimide and 1,7-dimorpholine-N,N'-(l-alanine t-butylester)-3,4:9,10-perylene diimide. Although there have been numerous photosensitizers, most of them have a limited useable range of solvent conditions or low photostability. These sensitizers

SUBMITTER: Ozcil F 

PROVIDER: S-EPMC10201336 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature