Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis.

ABSTRACT:

Objective

The aim of the study was to determine the mucosal microbiota associated with eosinophilic esophagitis (EoE) and eosinophilic gastritis (EoG) in a geographically diverse cohort of patients compared to controls.

Methods

We conducted a prospective study of individuals with eosinophilic gastrointestinal disease (EGID) in the Consortium of Eosinophilic Gastrointestinal Disease Researchers, including pediatric and adult tertiary care centers. Eligible individuals had clinical data, mucosal biopsies, and stool collected. Total bacterial load was determined from mucosal biopsy samples by quantitative polymerase chain reaction (PCR). Community composition was determined by small subunit rRNA gene amplicons.

Results

One hundred thirty-nine mucosal biopsies were evalua

SUBMITTER: Furuta GT 

PROVIDER: S-EPMC10201396 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature