Ontology highlight
ABSTRACT:
SUBMITTER: Altmannova V
PROVIDER: S-EPMC10201424 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Altmannova Veronika V Firlej Magdalena M Müller Franziska F Janning Petra P Rauleder Rahel R Rousova Dorota D Schäffler Andreas A Bange Tanja T Weir John R JR
Nucleic acids research 20230501 9
Crossing over between homologs is critical for the stable segregation of chromosomes during the first meiotic division. Saccharomyces cerevisiae Mer3 (HFM1 in mammals) is a SF2 helicase and member of the ZMM group of proteins, that facilitates the formation of the majority of crossovers during meiosis. Here, we describe the structural organisation of Mer3 and using AlphaFold modelling and XL-MS we further characterise the previously described interaction with Mlh1-Mlh2. We find that Mer3 also fo ...[more]