Ontology highlight
ABSTRACT:
SUBMITTER: Du Q
PROVIDER: S-EPMC10201437 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Du Qianhui Q Stow Emily C EC LaCoste Dawn D Freeman Benjamin B Baddoo Melody M Shareef Afzaal M AM Miller Kyle M KM Belancio Victoria P VP
Nucleic acids research 20230501 9
The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular factors through various mechanisms. Some of these factors are required for L1 amplification, while others either suppress or enhance specific steps during L1 propagation. Previously, TRIM28 has been identified to suppress transposable elements, including L1 expression via its canonical role in chromatin remodeling. Here, we report that TRIM28 through its B box domain increases L1 retrotransposition and facili ...[more]