Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats.

ABSTRACT:

Background

Sex differences play a critical role in the incidence and severity of cardiovascular diseases, whereby men are at a higher risk of developing cardiovascular disease compared to age-matched premenopausal women. Marked sex differences at the cellular and tissue level may contribute to susceptibility to cardiovascular disease and end-organ damage. In this study, we have performed an in-depth histological analysis of sex differences in hypertensive cardiac and renal injury in middle-aged stroke-prone spontaneously hypertensive rats (SHRSPs) to determine the interaction between age, sex and cell senescence.

Methods

Kidneys, hearts and urine samples were collected from 6.5- and 8-month-old (Mo) male and female SHRSPs. Urine samples were assayed for albumin and creatinin

SUBMITTER: Ansari A 

PROVIDER: S-EPMC10201739 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature