Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review.

ABSTRACT:

Background

The development of atrioventricular bioprosthesis has witnessed an increasing drive toward clinical translation over the last few decades. A significant challenge in the clinical translation of an atrioventricular bioprosthesis from bench to bedside is the appropriate choice of a large animal model to test the safety and effectiveness of the device.

Methods

We conducted a systematic review of pre-clinical in vivo studies that would enable us to synthesize a recommended framework. PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses) guidelines were followed to identify and extract relevant articles.

Results

Sheep was the most common choice of animal, with nine out of the 12 included studies being conducted on sheep. There were acute and

SUBMITTER: Sazzad F 

PROVIDER: S-EPMC10201874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature