Dataset Information

Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review.

ABSTRACT:

Background

The development of atrioventricular bioprosthesis has witnessed an increasing drive toward clinical translation over the last few decades. A significant challenge in the clinical translation of an atrioventricular bioprosthesis from bench to bedside is the appropriate choice of a large animal model to test the safety and effectiveness of the device.

Methods

We conducted a systematic review of pre-clinical in vivo studies that would enable us to synthesize a recommended framework. PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses) guidelines were followed to identify and extract relevant articles.

Results

Sheep was the most common choice of animal, with nine out of the 12 included studies being conducted on sheep. There were acute and chronic studies based on our search criteria. An average of ~20 and 5 animals were used for chronic and acute studies. One out of three acute studies and eight out of nine chronic studies were on stented heart valve bioprosthesis. All analyses were conducted on the implantation of atrioventricular valves with trileaflet, except for one chronic study on unileaflet valves and one chronic and acute study on bileaflet valves.

Conclusion

Understanding the variance in past pre-clinical study designs may increase the appropriate utilization of large animal models. This synthesized evidence provides a pre-clinical in vivo studies framework for future research on an atrioventricular bioprosthesis.

SUBMITTER: Sazzad F

PROVIDER: S-EPMC10201874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Preclinical Large Animal <i>In-Vivo</i> Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review.

Sazzad Faizus F Kollengode Ramanathan R Beverly Chan Li Xuan CLX Kiat Tan Ying TY Ganesh Geetha G Kofidis Theo T

Current cardiology reviews 20230101 1

<h4>Background</h4>The development of atrioventricular bioprosthesis has witnessed an increasing drive toward clinical translation over the last few decades. A significant challenge in the clinical translation of an atrioventricular bioprosthesis from bench to bedside is the appropriate choice of a large animal model to test the safety and effectiveness of the device.<h4>Methods</h4>We conducted a systematic review of pre-clinical in vivo studies that would enable us to synthesize a recommended ...[more]

PMID: 35718960

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