Responses Triggered by the Immune System in Hypertensive Conditions and Repercussions on Target Organ Damage: A Review.

ABSTRACT:

Background

Hypertension is a chronic, multifactorial clinical condition characterized by sustained high blood pressure levels. It is often associated with functional-structural alterations of target organs, which include heart, brain, kidneys, and vasculature.

Objective

This study highlights the recent correlation between the immune system and hypertension and its repercussions on target-organ damage.

Methods

The descriptors used for the search of the study were "hypertension", "immunity", and "target organs". The methodology of the study followed the main recommendations of the PRISMA statement.

Results

The damage to the vasculature arises mainly from the migration of T cells and monocytes that become pro-inflammatory in the adventitia, releasing TNF-α, IFN-γ,

SUBMITTER: da Silva CHND 

PROVIDER: S-EPMC10201903 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature