VPS72, a member of VPS protein family, can be used as a new prognostic marker for hepatocellular carcinoma.

ABSTRACT:

Background

Vacuolar protein sorting (VPS) plays a crucial role in intracellular molecular transport between organelles. However, studies have indicated a correlation between VPSs and tumorigenesis and the development of several cancers. Nevertheless, the association between VPSs and hepatocellular carcinoma (HCC) remains unclear.

Methods

By analyzing databases such as The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC), we investigated the differences in VPSs expression between normal tissue and HCC transcriptomes. Furthermore, we examined the relationship between VPSs expression and overall survival (OS) in patients with HCC. Univariate and multivariate Cox analyses were employed to assess the prognostic value of VPS72 as an independent fact

SUBMITTER: Huang J 

PROVIDER: S-EPMC10201960 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature