Impact of a prenatal screening program on the Down syndrome phenotype: An interrupted time series analysis.

ABSTRACT:

Introduction

We hypothesized that children with Down syndrome who were born after the implementation of first-trimester combined screening for trisomy 13, 18, and 21 and a second-trimester ultrasound scan in Denmark would show a milder syndrome phenotype. We investigated the birth biometry, prevalence of congenital malformations, and early childhood morbidity of children with Down syndrome before and after implementation of this screening program.

Material and methods

A nationwide register-based study of all live born singletons with Down syndrome in Denmark from 1995 to 2018. In interrupted time series analyses, we studied the temporal developments in birth biometry, prevalence of congenital malformations, and early childhood morbidity related to the implementation of a nat

SUBMITTER: Steffensen EH 

PROVIDER: S-EPMC10201969 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature