Identification of Key Diagnostic Markers and Immune Infiltration in Osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a worldwide chronic disease of the articulating joints. An increasing body of data demonstrates the immune system's involvement in osteoarthritis. The molecular mechanisms of OA are still unclear. This study aimed to search for OA immunerelated hub genes and determine appropriate diagnostic markers to help the detection and treatment of the disease.

Methods

Gene expression data were downloaded from the GEO database. Firstly, we analyzed and identified the differentially expressed genes (DEGs) using R packages. Meanwhile, ssGSEA was used to determine the activation degree of immune-related genes (IRGs), and WGCNA analysis was applied to search for co-expressed gene modules associated with immune cells. Then, critical networks and hub genes we

SUBMITTER: Yan M 

PROVIDER: S-EPMC10202085 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature