An open pore structure of the Orai channel, finally.

ABSTRACT: Store-operated Orai channels are a primary mechanism for mobilizing Ca²⁺ signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.

SUBMITTER: Prakriya M 

PROVIDER: S-EPMC10202095 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature