Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.

ABSTRACT:

Background

The Learning Early About Peanut allergy (LEAP) study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the Enquiring About Tolerance (EAT) study, a statistically significant reduction in PA was present only in per-protocol (PP) analyses, which can be subject to bias.

Objective

The aim of this study was to combine individual-level data from the LEAP and EAT trials and provide robust evidence on the bias-corrected, causal effect of early peanut introduction.

Method

As part of the European Union-funded iFAAM project, this pooled analysis of individual pediatric patient data combines and compares effectiveness and efficacy estimates of oral tolerance induction among different risk strata and analysis methods.

R

SUBMITTER: Logan K 

PROVIDER: S-EPMC10202125 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature