Impaired executive function exacerbates neural markers of posttraumatic stress disorder.

ABSTRACT:

Background

A major obstacle in understanding and treating posttraumatic stress disorder (PTSD) is its clinical and neurobiological heterogeneity. To address this barrier, the field has become increasingly interested in identifying subtypes of PTSD based on dysfunction in neural networks alongside cognitive impairments that may underlie the development and maintenance of symptoms. The current study aimed to determine if subtypes of PTSD, based on normative-based cognitive dysfunction across multiple domains, have unique neural network signatures.

Methods

In a sample of 271 veterans (90% male) that completed both neuropsychological testing and resting-state fMRI, two complementary, whole-brain functional connectivity analyses explored the link between brain functioning, PTSD s

SUBMITTER: Jagger-Rickels A 

PROVIDER: S-EPMC10202148 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature