Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control.

ABSTRACT: Additional treatment options for temporal lobe epilepsy are needed, and potential interventions targeting the cerebellum are of interest. Previous animal work has shown strong inhibition of hippocampal seizures through on-demand optogenetic manipulation of the cerebellum. However, decades of work examining electrical stimulation-a more immediately translatable approach-targeting the cerebellum has produced very mixed results. We were therefore interested in exploring the impact that stimulation parameters may have on seizure outcomes. Using a mouse model of temporal lobe epilepsy, we conducted on-demand electrical stimulation of the cerebellar cortex, and varied stimulation charge, frequency and pulse width, resulting in over 1000 different potential combinations of settings. To explore th

SUBMITTER: Stieve BJ 

PROVIDER: S-EPMC10202393 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature