Waning Effectiveness of the BNT162b2 Vaccine Against Infection in Adolescents in Israel.

ABSTRACT:

Background

The short-term effectiveness of a 2-dose regimen of the BioNTech/Pfizer BNT162b2 vaccine for adolescents has been demonstrated. However, little is known about the long-term effectiveness in this age group. It is known, however, that waning of vaccine-induced immunity against infection in adult populations is evident within a few months.

Methods

Leveraging the database of Maccabi Healthcare Services (MHS), we conducted a matched case-control design for evaluating the association between time since vaccination and the incidence of infections, where 2 outcomes were evaluated: documented SARS-CoV-2 infection (regardless of symptoms) and symptomatic infection (COVID-19). Cases were defined as individuals aged 12-16 with a positive polymerase chain reaction (PCR) test o

SUBMITTER: Prunas O 

PROVIDER: S-EPMC10202431 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature