Transmission of Carbapenem-Resistant Klebsiella pneumoniae in US Hospitals.

ABSTRACT:

Background

Carbapenem-resistant Klebsiella pneumoniae (CRKp) is the most prevalent carbapenem-resistant Enterobacterales in the United States. We evaluated CRKp clustering in patients in US hospitals.

Methods

From April 2016 to August 2017, 350 patients with clonal group 258 CRKp were enrolled in the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae, a prospective, multicenter, cohort study. A maximum likelihood tree was constructed using RAxML. Static clusters shared ≤21 single-nucleotide polymorphisms (SNP) and a most recent common ancestor. Dynamic clusters incorporated SNP distance, culture timing, and rates of SNP accumulation and transmission using the R program TransCluster.

Results

Most patients were admitted from home (n

SUBMITTER: Luterbach CL 

PROVIDER: S-EPMC10202433 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature