Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis.

ABSTRACT:

Background and aims

Atherosclerosis preferentially develops in arterial branches and curvatures where vascular endothelium is exposed to disturbed flow. In this study, the effects of disturbed flow on the regulation of vascular endothelial phosphoproteins and their contribution to therapeutic application in atherogenesis were elucidated.

Methods

Porcine models, large-scale phosphoproteomics, transgenic mice, and clinical specimens were used to discover novel site-specific phosphorylation alterations induced by disturbed flow in endothelial cells (ECs).

Results

A large-scale phosphoproteomics analysis of native endothelium from disturbed (athero-susceptible) vs. pulsatile flow (athero-resistant) regions of porcine aortas led to the identification of a novel atheroscler

SUBMITTER: Shih YT 

PROVIDER: S-EPMC10202442 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature