The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size.

ABSTRACT: Defective nutrient storage and adipocyte enlargement (hypertrophy) are emerging features of metabolic syndrome and type 2 diabetes. Within adipose tissues, how the cytoskeletal network contributes to adipose cell size, nutrient uptake, fat storage, and signaling remain poorly understood. Utilizing the Drosophila larval fat body (FB) as a model adipose tissue, we show that a specific actin isoform-Act5C-forms the cortical actin network necessary to expand adipocyte cell size for biomass storage in development. Additionally, we uncover a non-canonical role for the cortical actin cytoskeleton in inter-organ lipid trafficking. We find Act5C localizes to the FB cell surface and cell-cell boundaries, where it intimately contacts peripheral LDs (pLDs), forming a cortical actin network for

SUBMITTER: Ugrankar-Banerjee R 

PROVIDER: S-EPMC10202455 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature