Circulating CXCR5⁺ natural killer cells are expanded in patients with myasthenia gravis.

ABSTRACT:

Objectives

Myasthenia gravis (MG) is a classic autoantibody-mediated disease in which pathogenic antibodies target postsynaptic membrane components, causing fluctuating skeletal muscle weakness and fatigue. Natural killer (NK) cells are heterogeneous lymphocytes that have gained increasing attention owing to their potential roles in autoimmune disorders. This study will investigate the relationship between the distinct NK cell subsets and MG pathogenesis.

Methods

A total of 33 MG patients and 19 healthy controls were enrolled in the present study. Circulating NK cells, their subtypes and follicular helper T cells were analysed by flow cytometry. Serum acetylcholine receptor (AChR) antibody levels were determined by ELISA. The role of NK cells in the regulation of B cells was

SUBMITTER: Ge MR 

PROVIDER: S-EPMC10202622 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature