Vaping Dose, Device Type, and E-Liquid Flavor are Determinants of DNA Damage in Electronic Cigarette Users.

ABSTRACT:

Introduction

Despite the widespread use of electronic cigarettes, the long-term health consequences of vaping are largely unknown.

Aims and methods

We investigated the DNA-damaging effects of vaping as compared to smoking in healthy adults, including "exclusive" vapers (never smokers), cigarette smokers only, and nonusers, matched for age, gender, and race (N = 72). Following biochemical verification of vaping or smoking status, we quantified DNA damage in oral epithelial cells of our study subjects, using a long-amplicon quantitative polymerase chain reaction assay.

Results

We detected significantly increased levels of DNA damage in both vapers and smokers as compared to nonusers (p = .005 and p = .020, respectively). While the mean levels of DNA damage did not diffe

SUBMITTER: Tommasi S 

PROVIDER: S-EPMC10202635 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature