Age-related changes in lung function in National Center for Geriatrics and Gerontology Aging Farm C57BL/6N mice.

ABSTRACT: Aging is an extremely complex biological process, and various models, from unicellular organisms to mammals, have been used in its research. The mouse is the most widely used model for studying human aging and diseases due to its high homology and well-established strategies for genetic manipulation. Despite these advantages, the maximum lifespan of laboratory mice is nearly three years, which makes it time-consuming to obtain animals of the desired age. To avoid this issue and efficiently conduct aging research, the National Center for Geriatrics and Gerontology operates its "Aging Farm", a system that supplies aged animals in response to researchers' requests. In the present study, as part of the Aging Farm project, we examined changes in the physiological functions of the lungs and gene

SUBMITTER: Kawaguchi K 

PROVIDER: S-EPMC10202708 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature