Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.

ABSTRACT: Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previously found that post-operative patients showed an increase in endothelial cell-derived extracellular vesicles (eEVs) with components of coagulation and acute inflammatory responses. However, the mechanism underlying the onset of ALI owing to the release of eEVs after cardiopulmonary bypass, remains unclear. Plasma plasminogen-activated inhibitor-1 (PAI-1) and eEV levels were measured in patients with cardiopulmonary bypass. Endothelial cells and mice (C57BL/6, Toll-like receptor 4 knockout (TLR4^-/-) and inducible nitric oxide synthase knockout (iNOS^-/-)) were ch

SUBMITTER: Yuan HX 

PROVIDER: S-EPMC10202752 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature