[HSDL2 overexpression promotes rectal cancer progression by regulating cancer cell cycle and promoting cell proliferation].

ABSTRACT:

Objective

To analyze the expression of hydroxysteroid dehydrogenase like 2 (HSDL2) in rectal cancer tissues and the effect of changes in HSDL2 expression level on proliferation of rectal cancer cells.

Methods

Clinical data and tissue samples of 90 patients with rectal cancer admitted to our hospital from January 2020 to June 2022 were collected from the prospective clinical database and biological specimen database. The expression level of HSDL2 in rectal cancer and adjacent tissues was detected by immunohistochemistry, and based on the median level of HSDL2 expression, the patients were divided into high expression group (n=45) and low expression group (n=45) for analysis the correlation between HSDL2 expression level and the clinicopathological parameters. GO

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10202791 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature