A shared neural basis underlying psychiatric comorbidity.
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ABSTRACT:
SUBMITTER: Xie C
PROVIDER: S-EPMC10202801 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Publications
A shared neural basis underlying psychiatric comorbidity.
Xie Chao C Xiang Shitong S Shen Chun C Peng Xuerui X Kang Jujiao J Li Yuzhu Y Cheng Wei W He Shiqi S Bobou Marina M Bobou Marina M Broulidakis M John MJ van Noort Betteke Maria BM Zhang Zuo Z Robinson Lauren L Vaidya Nilakshi N Winterer Jeanne J Zhang Yuning Y King Sinead S Banaschewski Tobias T Barker Gareth J GJ Bokde Arun L W ALW Bromberg Uli U Büchel Christian C Flor Herta H Grigis Antoine A Garavan Hugh H Gowland Penny P Heinz Andreas A Ittermann Bernd B Lemaître Hervé H Martinot Jean-Luc JL Martinot Marie-Laure Paillère MP Nees Frauke F Orfanos Dimitri Papadopoulos DP Paus Tomáš T Poustka Luise L Fröhner Juliane H JH Schmidt Ulrike U Sinclair Julia J Smolka Michael N MN Stringaris Argyris A Walter Henrik H Whelan Robert R Desrivières Sylvane S Sahakian Barbara J BJ Robbins Trevor W TW Schumann Gunter G Jia Tianye T Feng Jianfeng J
Nature medicine 20230424 5
Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetical ...[more]
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