MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway.

ABSTRACT: Mesencephalic astrocyte-derived neurotrophic factor (MANF), an endoplasmic reticulum stress-inducible secreting protein, has evolutionarily conserved immune-regulatory function that contributes to the negative regulation of inflammation in macrophages. In this study, we investigated the profiles of MANF in the macrophages of the patients with active inflammatory bowel disease (IBD) and the mice with experimental colitis, which was induced in both myeloid cell-specific MANF knockout mice and wild-type mice by 3% dextran sodium sulfate (DSS) for 7 days. We found that MANF expression was significantly increased in intestinal macrophages from both the mice with experimental colitis and patients with active IBD. DSS-induced colitis was exacerbated in myeloid cell-specific MANF knockout mice. In

SUBMITTER: Yang L 

PROVIDER: S-EPMC10202914 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature