Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized ¹³C metabolic MRI.

ABSTRACT:

Background

In recent years, the ability of conventional magnetic resonance imaging (MRI), including T₁ contrast-enhanced (CE) MRI, to monitor high-efficacy therapies and predict long-term disability in multiple sclerosis (MS) has been challenged. Therefore, non-invasive methods to improve MS lesions detection and monitor therapy response are needed.

Methods

We studied the combined cuprizone and experimental autoimmune encephalomyelitis (CPZ-EAE) mouse model of MS, which presents inflammatory-mediated demyelinated lesions in the central nervous system as commonly seen in MS patients. Using hyperpolarized ¹³C MR spectroscopy (MRS) metabolic imaging, we measured cerebral metabolic fluxes in control, CPZ-EAE and CPZ-EAE mice treated with two clinically-rele

SUBMITTER: Guglielmetti C 

PROVIDER: S-EPMC10202949 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature