Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4⁺ T cells.

ABSTRACT: CD4⁺ T cells play major roles in the adaptive immune system, which requires antigen recognition, costimulation, and cytokines for its elaborate orchestration. Recent studies have provided new insight into the importance of the supramolecular activation cluster (SMAC), which comprises concentric circles and is involved in the amplification of CD4⁺ T cell activation. However, the underlying mechanism of SMAC formation remains poorly understood. Here, we performed single-cell RNA sequencing of CD4⁺ T cells left unstimulated and stimulated with anti-CD3 and anti-CD28 antibodies to identify novel proteins involved in their regulation. We found that intraflagellar transport 20 (IFT20), previously known as cilia-forming protein, was upregulated in antibody-stimula

SUBMITTER: Jeong J 

PROVIDER: S-EPMC10202954 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature